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Title: | Changes in the Prooxidant-antioxidant System of Rat Hearts Under the Complex Influence of Food Additives and Their Correction with Melatonin |
Authors: | Pshychenko, V. V. Cherno, V. S. Larycheva, O. M. Chebotar, L. D. Petrova, O. V. |
Keywords: | food additives rats heart oxidative stress |
Issue Date: | 2025 |
Publisher: | SCIENTIFIC SOC ANATOMISTS HISTOLOGISTS & EMBRYOLOGISTS UKRAINE |
Abstract: | This study presents the results of research on changes in the prooxidant-antioxidant system of rat hearts under the combined effect of food additives and the correction of pathological shifts with melatonin. It was established that the complex influence of sodium glutamate, the synthetic dye Ponceau 4R, and sodium nitrite leads to an increase in lipid peroxidation products in heart homogenates and multidirectional changes in the antioxidant defence system. Initially, these changes manifest as an increase in enzyme activity, followed by a decrease, indicating the development of oxidative stress and the depletion of the enzymatic component of the antioxidant system, with damage mechanisms prevailing over protective mechanisms. The administration of melatonin during the last ten days of the study contributed to a reduction in lipid peroxidation processes and improved the balance of the prooxidant-antioxidant system. Thus, exogenous melatonin is a potentially useful agent for correcting oxidative stress in the myocardium. |
Description: | Pshychenko, V. V., Cherno, V. S., Larycheva, O. M., Chebotar, L. D., & Petrova, O. I. (2025). Changes in the Prooxidant-antioxidant System of Rat Hearts Under the Complex Influence of Food Additives and Their Correction with Melatonin. World of Medicine and Biology, 91 (1), 181-185. DOI: 10.26724/2079-8334-2025-1-91-181-185 |
URI: | https://www.webofscience.com/wos/woscc/full-record/WOS:001461659300023 https://womab.com.ua/en/smb-2025-01/10536 https://dspace.chmnu.edu.ua/jspui/handle/123456789/2849 |
ISSN: | 2079-8334 |
Appears in Collections: | Публікації науково-педагогічних працівників ЧНУ імені Петра Могили у БД Web of Science |
Files in This Item:
File | Description | Size | Format | |
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CHANGES IN THE PROOXIDANT-ANTIOXIDANT SYSTEM.pdf | 293.56 kB | Adobe PDF | View/Open |
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