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DC Field | Value | Language |
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dc.contributor.author | Frenkel, Y. | - |
dc.contributor.author | Cherno, V. | - |
dc.contributor.author | Kostenko, H. | - |
dc.contributor.author | Chopra, H. | - |
dc.contributor.author | Gautam, R. K. | - |
dc.contributor.author | Kostenko, V. | - |
dc.date.accessioned | 2024-05-10T05:51:27Z | - |
dc.date.available | 2024-05-10T05:51:27Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 0928-4680 | - |
dc.identifier.issn | 1873-149X el. | - |
dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:001026049300001 | - |
dc.identifier.uri | https://www.mdpi.com/1873-149X/30/1/5 | - |
dc.identifier.uri | https://dspace.chmnu.edu.ua/jspui/handle/123456789/2203 | - |
dc.description | Frenkel, Y., Cherno, V., Kostenko, H., Chopra, H., Gautam, R. K., & Kostenko, V. (2023). Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting. Pathophysiology, 30 (1), 37-47. DOI: 10.3390/pathophysiology30010005 | uk_UA |
dc.description.abstract | This study aims to investigate the effect of resveratrol on systemic inflammatory response and metabolic disorder in rats fed a high-fructose high-lipid diet (HFHLD) and exposed to round-the-clock lighting (RCL). 21 adult male Wistar rats were randomly divided into 3 groups: control (group 1, n = 7); HFHLD for 8 weeks + round-the-clock lighting (RCL) (group 2, n = 7); HFHLD + RCL + Resveratrol (in a daily dose of 5 mg/kg intragastrically (group 3, n = 7). Results show that the combined effect of HFHLD and RCL reduces the serum melatonin (p < 0.001) and accelerates pro-inflammatory activities, oxidative stress, and metabolic disorder. There is a significant increase in the serum tumour necrosis factor-alpha (TNF-a) and C-reactive protein (CRP) (both p < 0.001), blood malondialdehyde-thiobarbituric acid adducts (MDA-TBA(2)) (p < 0.001), serum glucose (p < 0.01), insulin concentration, and the homeostatic model assessment insulin resistance (HOMA-IR) index (both p < 0.001), serum with very low-density lipoprotein (VLDL), and triacylglycerol (TAG) (both p < 0.001). At the same time, the decrease in the serum high-density lipoprotein (HDL) level (p < 0.001) is observed in the HFHLD + RCL group compared to the control. In the HFHLD + RCL + Resveratrol group, hypomelatonaemia (p < 0.001), pro-inflammatory actions, oxidative stress, and metabolic disorder were mitigated. Resveratrol can cause a significant rise in the serum melatonin and reduce serum TNF-a and CRP levels (both p < 0.001), blood MDA-TBA(2) (p < 0.001), serum glucose (both p < 0.01), insulin concentration, and HOMA-IR (both p < 0.001), serum VLDL and TAG (both p < 0.001) compared to the group 2, while serum HDL level increases (p < 0.01). Resveratrol attenuates pro-inflammatory responses and prevents considerable metabolic disorder in rats fed HFHLD under RCL. | uk_UA |
dc.language.iso | en | uk_UA |
dc.publisher | MDPI | uk_UA |
dc.subject | resveratrol | uk_UA |
dc.subject | high-fructose high-lipid diet | uk_UA |
dc.subject | light-dark cycle | uk_UA |
dc.subject | melatonin | uk_UA |
dc.subject | pro-inflammatory activity | uk_UA |
dc.subject | oxidative stress | uk_UA |
dc.subject | metabolic disorder | uk_UA |
dc.subject | rats | uk_UA |
dc.title | Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting | uk_UA |
dc.type | Article | uk_UA |
Appears in Collections: | Публікації науково-педагогічних працівників ЧНУ імені Петра Могили у БД Web of Science |
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Frenkel, Y., Cherno, V., Kostenko, H., Chopra, H., Gautam, R. K., & Kostenko, V..pdf | 467.39 kB | Adobe PDF | View/Open |
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